Could this be the answer to post viral and Long Covid fatigue?
When a cell comes under significant stress, it can move into a Cell Danger Response (CDR). Systemic inflammation responses place significant stress on cells trapped in the CDR. As a result, much of what has been seen with the spike protein injuries (from the vaccine or Long Covid) mirrors what has been seen in other complex disorders like Lyme disease and post viral syndromes.
Cells in the body are always at a different level of healing and stress. When too many cells in an area get trapped in their repair cycle and are unable to complete it, function of that area declines and can create a variety of disabling impairments.
Cells trapped in their repair cycle (the Cell Danger Response or CDR) are often the first weak link in the body that fails (e.g., during the aging process). Systemic inflammation places significant stress on cells trapped in the CDR. As a result, much of what has been seen with the spike protein injuries (from the vaccine or Long Covid) mirrors what has been seen in other complex disorders like Lyme disease, or post viral syndromes.
Restoration of the non-functional tissue by initiating the cellular repair cycle and resolving frozen repair cycles can resolve the situation. Because of this, many of the tools regenerative medicine has refined over decades for repairing non-healing injuries can also be applied to the understanding and treatment of debilitating inflammatory disorders.
The process of the Cell Danger Response essentially is as follows:
- Something stresses the cell.
- Mitochondria within the cell rapidly detect this stress before the stressor can kill the cell. This detection is due to electrons that previously were available to mitochondria being diverted to the stressor (e.g., an invading virus hijacking the cell to reproduce, a heavy metal being present, or many of the harmful [electron stealing] chemicals we are exposed to now), which creates a voltage drop in the mitochondria.
- Through quorum sensing, the stressed cells communicate the danger to other nearby cells, which then move into Cell Danger Response mode.
- The mitochondria then reduce or terminate their primary function (creating energy in the form of ATP for the cell) and switch from an anti-inflammatory to a pro-inflammatory state. As a result, ATP production is severely reduced, leading to crushing fatigue.
- Because the mitochondria producing ATP use up a lot of oxygen, once that production is reduced (or becomes incomplete) and the mitochondria shift to producing different biomolecules, the available oxygen in a cell rapidly increases. For context, mitochondria contain 1500 proteins tailored to meet the needs of each cell type and catalyze over 500 different chemical reactions in metabolism.
These mitochondrial effects (particularly the elevated oxygen) cause the following to occur:
- Production of complex proteins (polymers) is reduced, which viruses require to reproduce.
- Protective changes in the behavior of the whole organism (e.g., increased tiredness that induces the sleep needed to facilitate healing or a desire to isolate so the infection is not transferred to other members of their group).
- Antiviral and antimicrobial substances are released inside the cell.
- Warning cells in the vicinity that a danger is present.
- Increased consumption (autophagy) of components within the cell, including the defective parts of the mitochondria and the mitochondria themselves.
- Changes in gene expression and mobilization of parts of cellular DNA.
- The cell membrane stiffens so things are prevented from passing through it.
There are four mitochondrial complexes (numbered I through IV), collectively known as the electron transport chain, that lead to the production of ATP, and therefore energy for your cells. The process of energy production can be interrupted at any stage, but often the interruption is at Complex I or II, which has a knock on effect to Complex IV. This interruption can often be overcome by the supplementation with a high quality absorbable CoEnzyme Q10 based around Ubiquinol, along with nicotinamide adenine dinucleotide, (in the form of NAD+).
Ubiquinol is one of the two forms of CoEnzyme Q, and is the form that is preferentially distributed throughout the body, and overcomes some of the absorption challenges presented by CoEnzyme Q10 supplementation.
NAD+ plays a vital role in the processes of your body. NAD+ helps create cellular energy in mitochondrial Complexes I and II.
So if you suffer from a fatigue syndrome, supplementation with Ubiquinol and NAD+ might just be the thing to jumpstart your energy production.